If this is occurring on just one Security Profile, then this may be due to a corrupted profile. This can be tested by attempting to make and save the changes to the Security Profile by using the sa account, or a user in the MASTER profile (or copy of it).
Note: Please ensure the users belonging to the affected profile are logged out of Dimensions.
If the changes being made are still not saving, then this means the profile is corrupted. To resolve this, please do the following:
Ensure to be logged into Dimensions using the sa account or a user that sits on the default MASTER or a duplicate of MASTER profile.
On the System tab, click Users to view what profile(s) the relevant affected users are set against.
Click Security Profiles.
In the Security Profiles screen, go to the default MASTER profile
Use the Duplicate option to clone the profile, and fill in the Code and Name as required.
Adjust the profile permissions as required. Once completed, click Save.
Now that the profile has been saved, move across the required users into this new profile from the old corrupted profile.
The corrupted profile can now be deleted.
If this issue is happening across all Security Profiles and / or you notice it is happening for changes made only for particular modules, such as Invoice Register, then this can caused by different unlocks/licences being in use. If a user logs in to Dimensions with a licence that does not grant the use of particular modules, it can cause the settings for those modules in the Security Profiles to be disabled. First check you have the correct licence/unlock and then ensure the same licence is consistently applied across all machines by checking and registering a new unlock/licence.